Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study
Prevalence of Constipation in Elderly and Its Association With Dementia and Mild Cognitive Impairment: A Cross-Sectional Study
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BackgroundConstipation and dementia have 2 Layers Wood Sign similar epidemiological characteristics.Changes in intestinal flora and characteristics of the brain-gut axis play roles in the pathogeneses of the two diseases, suggesting that there may be a close connection between the two.Most of the studies on constipation in dementia patients have focused on the population with α-synucleinopathies [Parkinson’s disease dementia (PDD), dementia with Lewy bodies (DLB)].Few studies have reported the prevalence of constipation in all-cause dementia and mild cognitive impairment (MCI) populations.
ObjectiveTo assess the prevalence of constipation in patients with all-cause dementia and MCI subtypes and to explore the association between constipation with dementia and MCI subtypes.MethodsFrom May 2019 to December 2019, we conducted a population-based cross-sectional survey.A total of 11,743 participants aged 65 or older from nine cities in China were surveyed.Participants underwent a series of clinical examinations and neuropsychological measurements.
Constipation, dementia, MCI and MCI subtype were diagnosed according to established criteria through standard diagnostic procedures.ResultsThe overall age- and sex-adjusted prevalence of constipation in individuals aged 65 years and older was 14.8% (95% CI, 14.6–15.
0).The prevalence rates of constipation were19.2% (95% CI, 17.3–21.
0), 19.1% (95% CI, 16.8–21.5), 14.
4% (95% CI, 12.8–15.9), and 13.8% (95% CI, 13.
0–14.6) in the dementia, non-amnestic (na)-MCI, amnestic (a)-MCI and normal cognition populations, exfoliate respectively.Multivariate logistic regression analysis showed that higher prevalence of constipation was associated with dementia (p = 0.0.
032, OR = 1.18, 95% CI: 1.02–1.38) and na-MCI (p = 0.
003, OR = 1.30, 95% CI: 1.09–1.54).
ConclusionThe present study found a high prevalence of constipation in elderly individuals in China, and higher in patients with dementia and na-MCI.